Anti-SCN9A antibody [SAA1834] (STJA0020262)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2a
General Information
| Short Description | Mouse monoclonal Sodium Channel Protein Type 9 Subunit Alpha antibody for use in ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1834 |
| Isotype | IgG2a |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Protein A/G purified from cell culture supernatant |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Suitable for storage at +4Β°C between 1-2 weeks For longer term store at-20Β°C for up to 12 months |
Target Information
| Gene Symbol | SCN9A |
| Gene ID | 6335 |
| Uniprot ID | SCN9A_HUMAN |
Additional Info
| Post Translational Modifications | Phosphorylation at Ser-1490 by PKC in a highly conserved cytoplasmic loop increases peak sodium currents. Ubiquitinated by NEDD4L.which may promote its endocytosis. |
| Function | Pore-forming subunit of Nav1.7, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. Nav1.7 plays a crucial role in controlling the excitability and action potential propagation from nociceptor neurons, thereby contributing to the sensory perception of pain. |
| Protein Name | Sodium Channel Protein Type 9 Subunit AlphaNeuroendocrine Sodium ChannelHne-NaPeripheral Sodium Channel 1Pn1Sodium Channel Protein Type Ix Subunit AlphaVoltage-Gated Sodium Channel Subunit Alpha Nav1.7 |
| Database Links | Reactome: R-HSA-445095Reactome: R-HSA-5576892Reactome: R-HSA-9717207 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell ProjectionNeuron ProjectionAxonLocalizes To Neuron TerminalsAlso Detected At Nodes Of Ranvier |
| Alternative Antibody Names | Anti-Sodium Channel Protein Type 9 Subunit Alpha antibodyAnti-Neuroendocrine Sodium Channel antibodyAnti-Hne-Na antibodyAnti-Peripheral Sodium Channel 1 antibodyAnti-Pn1 antibodyAnti-Sodium Channel Protein Type Ix Subunit Alpha antibodyAnti-Voltage-Gated Sodium Channel Subunit Alpha Nav1.7 antibodyAnti-SCN9A antibodyAnti-NENA antibody |
Information sourced from Uniprot.org