Anti-SCN8A antibody (STJ192950)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Sodium channel protein type 8 subunit alpha for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20Β°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SCN8A |
| Gene ID | 6334 |
| Uniprot ID | SCN8A_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | SCN8A Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | May be ubiquitinated by NEDD4L.which would promote its endocytosis. Phosphorylation at Ser-1497 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents. |
| Function | Pore-forming subunit of a voltage-gated sodium channel complex assuming opened or closed conformations in response to the voltage difference across membranes and through which sodium ions selectively pass along their electrochemical gradient. Contributes to neuronal excitability by regulating action potential threshold and propagation. Isoform 5: More specifically expressed in non-neuronal cells, could play a role in sodium release from intracellular compartments and participate in the control of podosomes formation and macrophages adhesion and movement. |
| Protein Name | Sodium Channel Protein Type 8 Subunit AlphaSodium Channel Protein Type Viii Subunit AlphaVoltage-Gated Sodium Channel Subunit Alpha Nav1.6 |
| Database Links | Reactome: R-HSA-445095Reactome: R-HSA-5576892 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell ProjectionAxonMainly Localizes To The Axon Initial SegmentIsoform 5: Cytoplasmic VesiclePodosome |
| Alternative Antibody Names | Anti-Sodium Channel Protein Type 8 Subunit Alpha antibodyAnti-Sodium Channel Protein Type Viii Subunit Alpha antibodyAnti-Voltage-Gated Sodium Channel Subunit Alpha Nav1.6 antibodyAnti-SCN8A antibodyAnti-MED antibody |
Information sourced from Uniprot.org