| Short Description : | Rabbit polyclonal SCN4B (80-228) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | Scn4b |
| Gene ID: | 399548 |
| Uniprot ID: | SCN4B_MOUSE |
| Immunogen Region: | 80-228 |
| Immunogen Sequence: | IDGIVKNDKSDPKVRVKDDD RITLEGSTKEKTNNISILLS DLEFSDTGRYTCFVRNPKEK DLNNSATIFLQVVDKLEKVD NTVTLIILAVVGGVIGLLVC ILLLKKLITFILKKTREKKK ECLVSSSGNDNTENGLPGSK AEEKPPTKV |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 80-228 of mouse SCN4B (Q7M729). |
| Post Translational Modifications | Contains an interchain disulfide bond with SCN2A. |
| Function | Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. The accessory beta subunits participate in localization and functional modulation of the Nav channels. Modulates the activity of SCN1A/Nav1.1. Modulates the activity of SCN2A/Nav1.2. |
| Protein Name | Sodium Channel Regulatory Subunit Beta-4 |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Sodium Channel Regulatory Subunit Beta-4 antibodyAnti-Scn4b antibodyAnti-Gm1471 antibody |
Information sourced from Uniprot.org
