| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Sodium channel protein type 4 subunit alpha (431-480) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000IHC-p 1:50-300 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SCN4A |
| Gene ID: |
6329 |
| Uniprot ID: |
SCN4A_HUMAN |
| Immunogen Region: |
431-480 |
| Specificity: |
Na+ CP type IV Alpha Polyclonal Antibody detects endogenous levels of Na+ CP type IV Alpha protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from human SCN4A. AA range:431-480 |
| Function | Pore-forming subunit of Nav1.4, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. Highly expressed in skeletal muscles, Nav1.4 generates the action potential crucial for muscle contraction. |
| Protein Name | Sodium Channel Protein Type 4 Subunit AlphaSkm1Sodium Channel Protein Skeletal Muscle Subunit AlphaSodium Channel Protein Type Iv Subunit AlphaVoltage-Gated Sodium Channel Subunit Alpha Nav1.4 |
| Database Links | Reactome: R-HSA-445095Reactome: R-HSA-5576892 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Sodium Channel Protein Type 4 Subunit Alpha antibodyAnti-Skm1 antibodyAnti-Sodium Channel Protein Skeletal Muscle Subunit Alpha antibodyAnti-Sodium Channel Protein Type Iv Subunit Alpha antibodyAnti-Voltage-Gated Sodium Channel Subunit Alpha Nav1.4 antibodyAnti-SCN4A antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
