• Immunohistochemical analysis of paraffin-embedded human tonsil. 1, Antibody was diluted at 1:200 (4°C overnight). 2, Tris-EDTA, pH9.0 was used for antigen retrieval. 3, Secondary antibody was diluted at 1:200 (room temperature, 45min).

Anti-SCN1A antibody (STJ193174)

SKU:
STJ193174

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Sodium channel protein type 1 subunit alpha is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:40000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SCN1A
Gene ID: 6323
Uniprot ID: SCN1A_HUMAN
Specificity: This antibody detects endogenous levels of human SCN1A
Immunogen: Synthesized peptide derived from the human SCN1A
Function Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Plays a key role in brain, probably by regulating the moment when neurotransmitters are released in neurons. Involved in sensory perception of mechanical pain: activation in somatosensory neurons induces pain without neurogenic inflammation and produces hypersensitivity to mechanical, but not thermal stimuli.
Protein Name Sodium Channel Protein Type 1 Subunit Alpha
Sodium Channel Protein Brain I Subunit Alpha
Sodium Channel Protein Type I Subunit Alpha
Voltage-Gated Sodium Channel Subunit Alpha Nav1.1
Database Links Reactome: R-HSA-445095
Reactome: R-HSA-5576892
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Sodium Channel Protein Type 1 Subunit Alpha antibody
Anti-Sodium Channel Protein Brain I Subunit Alpha antibody
Anti-Sodium Channel Protein Type I Subunit Alpha antibody
Anti-Voltage-Gated Sodium Channel Subunit Alpha Nav1.1 antibody
Anti-SCN1A antibody
Anti-NAC1 antibody
Anti-SCN1 antibody

Information sourced from Uniprot.org

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