Anti-SCN11A antibody (Internal Region) (STJ13102081)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from the internal region of human Sodium channel protein type 11 subunit alpha (SCN11A, Nav1.9) conjugated to an immunogenic carrier protein was used as the immunogen.
General Information
| Short Description | Rabbit polyclonal anti-SCN11A (Internal Region) for use in IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | SCN11A |
| Gene ID | 11280 |
| Uniprot ID | SCNBA_HUMAN |
| Immunogen | A synthetic peptide from the internal region of human Sodium channel protein type 11 subunit alpha (SCN11A, Nav1.9) conjugated to an immunogenic carrier protein was used as the immunogen. |
| Immunogen Region | Internal Region |
| Specificity | Specific for SCN11A. |
Additional Info
| Function | Sodium channel mediating the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Involved in membrane depolarization during action potential in nociceptors which function as key relay stations for the electrical transmission of pain signals from the periphery to the central nervous system. Also involved in rapid BDNF-evoked neuronal depolarization. |
| Protein Name | Sodium Channel Protein Type 11 Subunit AlphaPeripheral Nerve Sodium Channel 5Pn5Sensory Neuron Sodium Channel 2Sodium Channel Protein Type Xi Subunit AlphaVoltage-Gated Sodium Channel Subunit Alpha Nav1.9Hnan |
| Database Links | Reactome: R-HSA-445095Reactome: R-HSA-5576892 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Sodium Channel Protein Type 11 Subunit Alpha antibodyAnti-Peripheral Nerve Sodium Channel 5 antibodyAnti-Pn5 antibodyAnti-Sensory Neuron Sodium Channel 2 antibodyAnti-Sodium Channel Protein Type Xi Subunit Alpha antibodyAnti-Voltage-Gated Sodium Channel Subunit Alpha Nav1.9 antibodyAnti-Hnan antibodyAnti-SCN11A antibodyAnti-SCN12A antibodyAnti-SNS2 antibody |
Information sourced from Uniprot.org