Anti-Scn10a/Nav1.8-Mouse antibody (Internal) (STJ72546)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-Scn10a/Nav1.8-Mouse (Internal) is suitable for use in ELISA research applications. |
| Applications | Pep-ELISA |
| Host | Goat |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Preliminary experiments gave an approx 150kDa band in Rat Spinal Cord and NIH3T3 lysates after 1µg/ml antibody staining. Please note that currently we cannot find an explanation in the |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | SCN10A |
| Gene ID | 6336 |
| Uniprot ID | SCNAA_HUMAN |
| Accession Number | NP_033160.2 |
| Immunogen Region | Internal |
| Immunogen Sequence | DDNRSLQSDPYNQR |
Additional Info
| Post Translational Modifications | Ubiquitinated by NEDD4L.which promotes its endocytosis. Phosphorylation at Ser-1451 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents. Lacks the cysteine which covalently binds the conotoxin GVIIJ. This cysteine (position 816) is speculated in other sodium channel subunits alpha to be implied in covalent binding with the sodium channel subunit beta-2 or beta-4. |
| Function | Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms. |
| Protein Name | Sodium Channel Protein Type 10 Subunit AlphaPeripheral Nerve Sodium Channel 3Pn3Hpn3Sodium Channel Protein Type X Subunit AlphaVoltage-Gated Sodium Channel Subunit Alpha Nav1.8 |
| Database Links | Reactome: R-HSA-445095Reactome: R-HSA-5576892 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinIt Can Be Translocated To The Cell Membrane Through Association With S100a10 |
| Alternative Antibody Names | Anti-Sodium Channel Protein Type 10 Subunit Alpha antibodyAnti-Peripheral Nerve Sodium Channel 3 antibodyAnti-Pn3 antibodyAnti-Hpn3 antibodyAnti-Sodium Channel Protein Type X Subunit Alpha antibodyAnti-Voltage-Gated Sodium Channel Subunit Alpha Nav1.8 antibodyAnti-SCN10A antibody |
Information sourced from Uniprot.org