Anti-SCN10A antibody (STJ191434)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Sodium channel protein type 10 subunit alpha for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SCN10A |
| Gene ID | 6336 |
| Uniprot ID | SCNAA_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | SCNAA Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Ubiquitinated by NEDD4L.which promotes its endocytosis. Phosphorylation at Ser-1451 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents. Lacks the cysteine which covalently binds the conotoxin GVIIJ. This cysteine (position 816) is speculated in other sodium channel subunits alpha to be implied in covalent binding with the sodium channel subunit beta-2 or beta-4. |
| Function | Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms. |
| Protein Name | Sodium Channel Protein Type 10 Subunit AlphaPeripheral Nerve Sodium Channel 3Pn3Hpn3Sodium Channel Protein Type X Subunit AlphaVoltage-Gated Sodium Channel Subunit Alpha Nav1.8 |
| Database Links | Reactome: R-HSA-445095Reactome: R-HSA-5576892 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinIt Can Be Translocated To The Cell Membrane Through Association With S100a10 |
| Alternative Antibody Names | Anti-Sodium Channel Protein Type 10 Subunit Alpha antibodyAnti-Peripheral Nerve Sodium Channel 3 antibodyAnti-Pn3 antibodyAnti-Hpn3 antibodyAnti-Sodium Channel Protein Type X Subunit Alpha antibodyAnti-Voltage-Gated Sodium Channel Subunit Alpha Nav1.8 antibodyAnti-SCN10A antibody |
Information sourced from Uniprot.org