| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SCG3 (199-468) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SCG3 |
| Gene ID: |
29106 |
| Uniprot ID: |
SCG3_HUMAN |
| Immunogen Region: |
199-468 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 199-468 of human SCG3 (NP_037375.2). |
| Immunogen Sequence: |
KLISKEANNYEEDPNKPTSW TENQAGKIPEKVTPMAAIQD GLAKGENDETVSNTLTLTNG LERRTKTYSEDNFEELQYFP NFYALLKSIDSEKEAKEKET LITIMKTLIDFVKMMVKYGT ISPEEGVSYLENLDEMIALQ TKNKLEKNATDNISKLFPAP SEKSHEETDSTKEEAAKMEK EYGSLKDSTKDDNSNPGGKT DEPKGKTEAYLEAIRKNIEW LKKHDKKGNKEDYDLSKMR |
| Tissue Specificity | Detected in urine (at protein level). Expressed in brain, heart, kidney, liver and skeletal muscle. |
| Post Translational Modifications | O-glycosylated. |
| Function | Member of the granin protein family that regulates the biogenesis of secretory granules. Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA. May also play a role in angiogenesis. Promotes endothelial proliferation, migration and tube formation through MEK/ERK signaling pathway. |
| Protein Name | Secretogranin-3Secretogranin IiiSgiii |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
| Cellular Localisation | Cytoplasmic VesicleSecretory VesicleSecretory Vesicle MembranePeripheral Membrane ProteinSecretedAssociated With The Secretory Granule Membrane Through Direct Binding To Cholesterol-Enriched Lipid Rafts |
| Alternative Antibody Names | Anti-Secretogranin-3 antibodyAnti-Secretogranin Iii antibodyAnti-Sgiii antibodyAnti-SCG3 antibodyAnti-UNQ2502 antibodyAnti-PRO5990 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
