| Host: |
Rabbit |
| Applications: |
WB/IHC/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SCD (25-43) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IHC-P 1:50-1:200IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SCD |
| Gene ID: |
6319 |
| Uniprot ID: |
SCD_HUMAN |
| Immunogen Region: |
25-43 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 25-43 of human SCD (NP_005054.3). |
| Immunogen Sequence: |
SRVLQNGGDKLETMPLYLE |
| Tissue Specificity | Detected in fetal liver, lung and brain. Highly expressed in adult adipose tissue, and at lower levels in adult brain and lung. |
| Function | Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA. Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids. Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation. Plays an important role in body energy homeostasis. Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides. |
| Protein Name | Stearoyl-Coa DesaturaseHscd1Acyl-Coa DesaturaseDelta(9-DesaturaseDelta-9 DesaturaseFatty Acid Desaturase |
| Database Links | Reactome: R-HSA-2426168Reactome: R-HSA-75105Reactome: R-HSA-9029558 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Stearoyl-Coa Desaturase antibodyAnti-Hscd1 antibodyAnti-Acyl-Coa Desaturase antibodyAnti-Delta(9-Desaturase antibodyAnti-Delta-9 Desaturase antibodyAnti-Fatty Acid Desaturase antibodyAnti-SCD antibodyAnti-FADS5 antibodyAnti-SCD1 antibodyAnti-SCDOS antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Immunofluorescence analysis of MCF7 cells using [KD Validated] SCD Rabbit polyclonal antibody (STJ11105577) at a dilution of 1:100 (40x lens). Secondary antibody:Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/178221/370505/STJ11105577_1__69759.1713136460.jpg?c=1 "Immunofluorescence analysis of MCF7 cells using [KD Validated] SCD Rabbit polyclonal antibody (STJ11105577) at a dilution of 1:100 (40x lens). Secondary antibody:Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.")
