• STJ73352 (0. 03µg/ml) staining of Human Adrenal Gland lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-SCARB1/SR-BI antibody (238-250) (STJ73352)

SKU:
STJ73352-100

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Host: Goat
Applications: Pep-ELISA/WB/IHC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-SCARB1/SR-BI (238-250) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: WB-0.01-0.03µg/ml
IHC-5µg/ml
ELISA-antibody detection limit dilution 1:128000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: SCARB1
Gene ID: 949
Uniprot ID: SCRB1_HUMAN
Immunogen Region: 238-250
Accession Number: NP_005496.4; NP_001076428.1
Specificity: This antibody is expected to recognize both reported isoforms (NP_005496.4; NP_001076428.1).
Immunogen Sequence: NGLSKVDFWHSDQ
Post Translational Modifications N-glycosylated. The six cysteines of the extracellular domain are all involved in intramolecular disulfide bonds.
Function Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. (Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes and appears to facilitate its cell entry. Binding between SCARB1 and the hepatitis C virus glycoprotein E2 is independent of the genotype of the viral isolate. (Microbial infection) Mediates uptake of M.fortuitum, E.coli and S.aureus. (Microbial infection) Facilitates the entry of human coronavirus SARS-CoV-2 by acting as an entry cofactor through HDL binding.
Protein Name Scavenger Receptor Class B Member 1
Srb1
Cd36 And Limpii Analogous 1
Cla-1
Cd36 Antigen-Like 1
Collagen Type I Receptor - Thrombospondin Receptor-Like 1
Sr-Bi
Cd Antigen Cd36
Database Links Reactome: R-HSA-3000471 Q8WTV0-2
Reactome: R-HSA-8964011 Q8WTV0-2
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Membrane
Caveola
Predominantly Localized To Cholesterol And Sphingomyelin-Enriched Domains Within The Plasma Membrane
Called Caveolae
Alternative Antibody Names Anti-Scavenger Receptor Class B Member 1 antibody
Anti-Srb1 antibody
Anti-Cd36 And Limpii Analogous 1 antibody
Anti-Cla-1 antibody
Anti-Cd36 Antigen-Like 1 antibody
Anti-Collagen Type I Receptor - Thrombospondin Receptor-Like 1 antibody
Anti-Sr-Bi antibody
Anti-Cd Antigen Cd36 antibody
Anti-SCARB1 antibody
Anti-CD36L1 antibody
Anti-CLA1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance