• Immunohistochemistry analysis of SCAF4 in paraffin-embedded rat brain using SCAF4 Rabbit polyclonal antibody (STJ11103425) at dilution of 1:50 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.
  • Immunohistochemistry analysis of SCAF4 in paraffin-embedded mouse pancreas using SCAF4 Rabbit polyclonal antibody (STJ11103425) at dilution of 1:50 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.
  • Immunohistochemistry analysis of SCAF4 in paraffin-embedded human placenta using SCAF4 Rabbit polyclonal antibody (STJ11103425) at dilution of 1:50 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.
  • Immunohistochemistry analysis of SCAF4 in paraffin-embedded human esophagus using SCAF4 Rabbit polyclonal antibody (STJ11103425) at dilution of 1:50 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.

Anti-SCAF4 antibody (170-248) (STJ11103425)

SKU:
STJ11103425

$151.88 - $705.38
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Host: Rabbit
Applications: WB/IHC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-SCAF4 (170-248) is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
IHC-P 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SCAF4
Gene ID: 57466
Uniprot ID: SCAF4_HUMAN
Immunogen Region: 170-248
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 170-248 of human SCAF4 (NP_065757.1).
Immunogen Sequence: TPNSVPAVPQLPSSDAFAAV AQLFQTTQGQQLQQILQTFQ QPPKPQSPALDNAVMAQVQA ITAQLKTTPTQPSEQKAAF
Function Anti-terminator protein required to prevent early mRNA termination during transcription. Together with SCAF8, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins. Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation. Independently of SCAF8, also acts as a suppressor of transcriptional readthrough.
Protein Name Sr-Related And Ctd-Associated Factor 4
Ctd-Binding Sr-Like Protein Ra4
Splicing Factor - Arginine/Serine-Rich 15
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Sr-Related And Ctd-Associated Factor 4 antibody
Anti-Ctd-Binding Sr-Like Protein Ra4 antibody
Anti-Splicing Factor - Arginine/Serine-Rich 15 antibody
Anti-SCAF4 antibody
Anti-KIAA1172 antibody
Anti-SFRS15 antibody

Information sourced from Uniprot.org

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