| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SBDS (1-250) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SBDS |
| Gene ID: |
51119 |
| Uniprot ID: |
SBDS_HUMAN |
| Immunogen Region: |
1-250 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human SBDS (NP_057122.2). |
| Immunogen Sequence: |
MSIFTPTNQIRLTNVAVVRM KRAGKRFEIACYKNKVVGWR SGVEKDLDEVLQTHSVFVNV SKGQVAKKEDLISAFGTDDQ TEICKQILTKGEVQVSDKER HTQLEQMFRDIATIVADKCV NPETKRPYTVILIERAMKDI HYSVKTNKSTKQQALEVIKQ LKEKMKIERAHMRLRFILPV NEGKKLKEKLKPLIKVIESE DYGQQLEIVCLIDPGCFREI DELIKKETKGKGSLEVLNL |
| Tissue Specificity | Widely expressed. |
| Function | Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation. |
| Protein Name | Ribosome Maturation Protein SbdsShwachman-Bodian-Diamond Syndrome Protein |
| Cellular Localisation | CytoplasmNucleusNucleolusNucleoplasmCytoskeletonSpindlePrimarily Detected In The CytoplasmAnd At Low Levels In Nucleus And NucleolusDetected In The Nucleolus During G1 And G2 Phase Of The Cell CycleAnd Diffusely Distributed In The Nucleus During S PhaseDetected At The Mitotic SpindleColocalizes With The Microtubule Organizing Center During Interphase |
| Alternative Antibody Names | Anti-Ribosome Maturation Protein Sbds antibodyAnti-Shwachman-Bodian-Diamond Syndrome Protein antibodyAnti-SBDS antibodyAnti-CGI-97 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
