Anti-SATB2 antibody (650-730 aa) (STJ190433)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 650-730
General Information
| Short Description | Rabbit polyclonal anti-DNA-binding protein SATB2 (650-730 aa) for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SATB2 |
| Gene ID | 23314 |
| Uniprot ID | SATB2_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 650-730 |
| Immunogen Region | 650-730 aa |
| Specificity | SATB2 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Sumoylated by PIAS1. Sumoylation promotes nuclear localization, but represses transcription factor activity. |
| Function | Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation. |
| Protein Name | Dna-Binding Protein Satb2Special At-Rich Sequence-Binding Protein 2 |
| Database Links | Reactome: R-HSA-4551638Reactome: R-HSA-8940973 |
| Cellular Localisation | Nucleus Matrix |
| Alternative Antibody Names | Anti-Dna-Binding Protein Satb2 antibodyAnti-Special At-Rich Sequence-Binding Protein 2 antibodyAnti-SATB2 antibodyAnti-KIAA1034 antibody |
Information sourced from Uniprot.org