| Short Description : | Rabbit polyclonal SARS (1-300) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SARS1 |
| Gene ID: | 6301 |
| Uniprot ID: | SYSC_HUMAN |
| Immunogen Region: | 1-300 |
| Immunogen Sequence: | MVLDLDLFRVDKGGDPALIR ETQEKRFKDPGLVDQLVKAD SEWRRCRFRADNLNKLKNLC SKTIGEKMKKKEPVGDDESV PENVLSFDDLTADALANLKV SQIKKVRLLIDEAILKCDAE RIKLEAERFENLREIGNLLH PSVPISNDEDVDNKVERIWG DCTVRKKYSHVDLVVMVDGF EGEKGAVVAGSRGYFLKGVL VFLEQALIQYALRTLGSRGY IPIYTPFFMRKEVMQEVAQ |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human SARS (NP_006504.2). |
| Tissue Specificity | Brain. |
| Function | Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC. Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA. |
| Protein Name | Serine--Trna Ligase - CytoplasmicSeryl-Trna SynthetaseSerrsSeryl-Trna(Ser/Sec Synthetase |
| Database Links | Reactome: R-HSA-2408557Reactome: R-HSA-379716 |
| Cellular Localisation | CytoplasmNucleusPredominantly CytoplasmicBut A Minor Proportion Is Also Found In The Nucleus |
| Alternative Antibody Names | Anti-Serine--Trna Ligase - Cytoplasmic antibodyAnti-Seryl-Trna Synthetase antibodyAnti-Serrs antibodyAnti-Seryl-Trna(Ser/Sec Synthetase antibodyAnti-SARS1 antibodyAnti-SARS antibodyAnti-SERS antibody |
Information sourced from Uniprot.org
