Anti-SAP97 antibody [R06-6C8] (STJA0035356)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human SAP97
General Information
| Short Description | Rabbit monoclonal anti-SAP97 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R06-6C8 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | DLG1 |
| Gene ID | 1739 |
| Uniprot ID | DLG1_HUMAN |
| Immunogen | A synthetic peptide of human SAP97 |
Additional Info
| Tissue Specificity | Abundantly expressed in atrial myocardium (at protein level). Expressed in lung fibroblasts, cervical epithelial and B-cells (at protein level). Expressed in the brain (at protein level). Widely expressed, with isoforms displaying different expression profiles. |
| Post Translational Modifications | Phosphorylated by MAPK12. Phosphorylation of Ser-232 regulates association with GRIN2A. Ubiquitinated.by MARCHF2 which results in its degradation. |
| Function | Essential multidomain scaffolding protein required for normal development. Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion. May also play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel. During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane. |
| Protein Name | Disks Large Homolog 1Synapse-Associated Protein 97Sap-97Sap97Hdlg |
| Database Links | Reactome: R-HSA-399719Reactome: R-HSA-438066Reactome: R-HSA-442982Reactome: R-HSA-447038Reactome: R-HSA-451308Reactome: R-HSA-5673001Reactome: R-HSA-8849932Reactome: R-HSA-9609736Reactome: R-HSA-9617324Reactome: R-HSA-9620244 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinBasolateral Cell MembraneEndoplasmic Reticulum MembranePostsynaptic DensitySynapseSarcolemmaApical Cell MembraneCell JunctionCytoplasmColocalizes With Epb41 At Regions Of Intercellular ContactsBasolateral In Epithelial CellsMay Also Associate With Endoplasmic Reticulum MembranesMainly Found In Neurons SomaModerately Found At Postsynaptic Densities |
| Alternative Antibody Names | Anti-Disks Large Homolog 1 antibodyAnti-Synapse-Associated Protein 97 antibodyAnti-Sap-97 antibodyAnti-Sap97 antibodyAnti-Hdlg antibodyAnti-DLG1 antibody |
Information sourced from Uniprot.org