Anti-Sap30l-Mouse antibody (C-Term) (STJ72483)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-Sap30l-Mouse (C-Term) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Dog |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Approx 18kDa band observed in Rat Spleen lysates (calculated MW of 20.8kDa according to Rat XP_340804.4). Recommended concentration: 0.3-1µg/ml. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | SAP30L |
| Gene ID | 79685 |
| Uniprot ID | SP30L_HUMAN |
| Accession Number | NP_001074637.1 |
| Immunogen Region | C-Term |
| Immunogen Sequence | RLDQKSEGSKQLE |
Additional Info
| Function | Isoform 1: Functions as a transcription repressor, probably via its interaction with histone deacetylase complexes. Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus. Binds DNA, apparently without sequence-specificity, and bends bound double-stranded DNA. Binds phosphoinositol phosphates (phosphoinositol 3-phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate) via the same basic sequence motif that mediates DNA binding and nuclear import. Isoform 2: Functions as a transcription repressor.isoform 2 has lower transcription repressor activity than isoform 1 and isoform 3. Isoform 3: Functions as a transcription repressor.its activity is marginally lower than that of isoform 1. |
| Protein Name | Histone Deacetylase Complex Subunit Sap30lHcv Non-Structural Protein 4a-Transactivated Protein 2Sin3 Corepressor Complex Subunit Sap30lSin3-Associated Protein P30-Like |
| Database Links | Reactome: R-HSA-3214815Reactome: R-HSA-427413Reactome: R-HSA-9679191 |
| Cellular Localisation | Isoform 1: NucleusNucleolusIsoform 2: NucleusIsoform 3: Nucleus |
| Alternative Antibody Names | Anti-Histone Deacetylase Complex Subunit Sap30l antibodyAnti-Hcv Non-Structural Protein 4a-Transactivated Protein 2 antibodyAnti-Sin3 Corepressor Complex Subunit Sap30l antibodyAnti-Sin3-Associated Protein P30-Like antibodyAnti-SAP30L antibodyAnti-NS4ATP2 antibody |
Information sourced from Uniprot.org