Anti-SAG antibody (1-405) (STJ115012)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SAG (1-405) antibody for use in WB, IHC-P and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SAG |
| Gene ID | 6295 |
| Uniprot ID | ARRS_HUMAN |
| Immunogen Region | 1-405 |
| Immunogen Sequence | MAASGKTSKSEPNHVIFKKI SRDKSVTIYLGNRDYIDHVS QVQPVDGVVLVDPDLVKGKK VYVTLTCAFRYGQEDIDVIG LTFRRDLYFSRVQVYPPVGA ASTPTKLQESLLKKLGSNTY PFLLTFPDYLPCSVMLQPAP QDSGKSCGVDFEVKAFATDS TDAEEDKIPKKSSVRLLIRK VQHAPLEMGPQPRAEAAWQF FMSDKPLHLAVSLNKEIYFH GEPIPVTVTVTNNTEKTVK |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-405 of human SAG (NP_000532.2). |
Additional Info
| Tissue Specificity | Detected in retina, in the proximal portion of the outer segment of rod photoreceptor cells (at protein level). |
| Function | Binds to photoactivated, phosphorylated RHO and terminates RHO signaling via G-proteins by competing with G-proteins for the same binding site on RHO. May play a role in preventing light-dependent degeneration of retinal photoreceptor cells. |
| Protein Name | S-Arrestin48 Kda ProteinRetinal S-AntigenS-AgRod Photoreceptor Arrestin |
| Database Links | Reactome: R-HSA-2485179Reactome: R-HSA-2514859 |
| Cellular Localisation | Cell ProjectionCiliumPhotoreceptor Outer SegmentMembranePeripheral Membrane ProteinHighly Expressed In Photoreceptor Outer Segments In Light-Exposed RetinaEvenly Distributed Throughout Rod Photoreceptor Cells In Dark-Adapted RetinaPredominantly Dectected At The Proximal Region Of Photoreceptor Outer SegmentsNear Disk Membranes |
| Alternative Antibody Names | Anti-S-Arrestin antibodyAnti-48 Kda Protein antibodyAnti-Retinal S-Antigen antibodyAnti-S-Ag antibodyAnti-Rod Photoreceptor Arrestin antibodyAnti-SAG antibody |
Information sourced from Uniprot.org