Anti-SACM1L antibody (STJA0006898)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human SACM1L
General Information
| Short Description | Rabbit polyclonal anti-Phosphatidylinositol-3-phosphatase SAC1 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SACM1L |
| Gene ID | 22908 |
| Uniprot ID | SAC1_HUMAN |
| Immunogen | Synthesized peptide derived from human SACM1L |
| Specificity | This antibody detects endogenous levels of SACM1L at Human, Mouse, Rat |
Additional Info
| Function | Phosphoinositide phosphatase which catalyzes the hydrolysis of phosphatidylinositol 4-phosphate (PtdIns(4)P). Can also catalyze the hydrolysis of phosphatidylinositol 3-phosphate (PtdIns(3)P) and has low activity towards phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2). Shows a very robust PtdIns(4)P phosphatase activity when it binds PtdIns(4)P in a 'cis' configuration in the cellular environment, with much less activity seen when it binds PtdIns(4)P in 'trans' configuration. PtdIns(4)P phosphatase activity (when it binds PtdIns(4)P in 'trans' configuration) is enhanced in the presence of PLEKHA3. |
| Protein Name | Phosphatidylinositol-3-Phosphatase Sac1Phosphatidylinositol-4-Phosphate PhosphataseSuppressor Of Actin Mutations 1-Like Protein |
| Database Links | Reactome: R-HSA-1483248Reactome: R-HSA-1660514 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinGolgi Apparatus MembraneTrafficking Between The Er And Golgi Is Regulated By Nutrient Status And By Tmem39aLocalizes To Endoplasmic Reticulum-Plasma Membrane Contact Sites (Epcs) In The Presence Of Phosphatidylinositol-45-Bisphosphate |
| Alternative Antibody Names | Anti-Phosphatidylinositol-3-Phosphatase Sac1 antibodyAnti-Phosphatidylinositol-4-Phosphate Phosphatase antibodyAnti-Suppressor Of Actin Mutations 1-Like Protein antibodyAnti-SACM1L antibodyAnti-KIAA0851 antibodyAnti-SAC1 antibody |
Information sourced from Uniprot.org