| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
SACM1L |
| Gene ID: |
22908 |
| Uniprot ID: |
SAC1_HUMAN |
| Immunogen Region: |
350-520 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 350-520 of human SACM1L (NP_054735.3). |
| Immunogen Sequence: |
DRLSILLDQVAEMQDELSYF LVDSAGQVVANQEGVFRSNC MDCLDRTNVIQSLLARRSLQ AQLQRLGVLHVGQKLEEQDE FEKIYKNAWADNANACAKQY AGTGALKTDFTRTGKRTHLG LIMDGWNSMIRYYKNNFSDG FRQDSIDLFLGNYSVDELES HSPLSVPRDWK |
| Tissue Specificity | Detected in heart, brain, lung, liver, kidney, pancreas and testis. |
| Function | Phosphoinositide phosphatase which catalyzes the hydrolysis of phosphatidylinositol 4-phosphate (PtdIns(4)P). Can also catalyze the hydrolysis of phosphatidylinositol 3-phosphate (PtdIns(3)P) and has low activity towards phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2). Shows a very robust PtdIns(4)P phosphatase activity when it binds PtdIns(4)P in a 'cis' configuration in the cellular environment, with much less activity seen when it binds PtdIns(4)P in 'trans' configuration. PtdIns(4)P phosphatase activity (when it binds PtdIns(4)P in 'trans' configuration) is enhanced in the presence of PLEKHA3. |
| Protein Name | Phosphatidylinositol-3-Phosphatase Sac1Phosphatidylinositol-4-Phosphate PhosphataseSuppressor Of Actin Mutations 1-Like Protein |
| Database Links | Reactome: R-HSA-1483248Reactome: R-HSA-1660514 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinGolgi Apparatus MembraneTrafficking Between The Er And Golgi Is Regulated By Nutrient Status And By Tmem39aLocalizes To Endoplasmic Reticulum-Plasma Membrane Contact Sites (Epcs) In The Presence Of Phosphatidylinositol-45-Bisphosphate |
| Alternative Antibody Names | Anti-Phosphatidylinositol-3-Phosphatase Sac1 antibodyAnti-Phosphatidylinositol-4-Phosphate Phosphatase antibodyAnti-Suppressor Of Actin Mutations 1-Like Protein antibodyAnti-SACM1L antibodyAnti-KIAA0851 antibodyAnti-SAC1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
