Anti-RUNX3 antibody (200-250) {FITC} (STJ502845)

SKU:
STJ502845-100

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Host: Rabbit
Applications: ELISA/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-RUNX3 (200-250) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: FITC
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.52-0.53 µg/µl
Dilution Range: WB: 1:500
DB: 1:10, 000
ELISA: 1:10, 000
IP: 1:150
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: RUNX3
Gene ID: 864
Uniprot ID: RUNX3_HUMAN
Immunogen Region: 200-250
Immunogen: Synthetic peptide taken within amino acid region 200-250 on human Runt-related transcription factor 3 protein.
Tissue Specificity Expressed in gastric cancer tissues (at protein level).
Post Translational Modifications Phosphorylated on tyrosine residues by SRC. Phosphorylated by LCK and FYN.
Function Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters. May be involved in the control of cellular proliferation and/or differentiation. In association with ZFHX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing.
Protein Name Runt-Related Transcription Factor 3
Acute Myeloid Leukemia 2 Protein
Core-Binding Factor Subunit Alpha-3
Cbf-Alpha-3
Oncogene Aml-2
Polyomavirus Enhancer-Binding Protein 2 Alpha C Subunit
Pea2-Alpha C
Pebp2-Alpha C
Sl3-3 Enhancer Factor 1 Alpha C Subunit
Sl3/Akv Core-Binding Factor Alpha C Subunit
Database Links Reactome: R-HSA-4411364
Reactome: R-HSA-8941855
Reactome: R-HSA-8941856
Reactome: R-HSA-8941858
Reactome: R-HSA-8949275
Reactome: R-HSA-8951430
Reactome: R-HSA-8951671
Reactome: R-HSA-8951911
Reactome: R-HSA-8951936
Reactome: R-HSA-8952158
Cellular Localisation Nucleus
Cytoplasm
The Tyrosine Phosphorylated Form Localizes To The Cytoplasm
Translocates From The Cytoplasm To The Nucleus Following Tgf-Beta Stimulation
Alternative Antibody Names Anti-Runt-Related Transcription Factor 3 antibody
Anti-Acute Myeloid Leukemia 2 Protein antibody
Anti-Core-Binding Factor Subunit Alpha-3 antibody
Anti-Cbf-Alpha-3 antibody
Anti-Oncogene Aml-2 antibody
Anti-Polyomavirus Enhancer-Binding Protein 2 Alpha C Subunit antibody
Anti-Pea2-Alpha C antibody
Anti-Pebp2-Alpha C antibody
Anti-Sl3-3 Enhancer Factor 1 Alpha C Subunit antibody
Anti-Sl3/Akv Core-Binding Factor Alpha C Subunit antibody
Anti-RUNX3 antibody
Anti-AML2 antibody
Anti-CBFA3 antibody
Anti-PEBP2A3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance