| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RTN4RL1 (220-420) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:4000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RTN4RL1 |
| Gene ID: |
146760 |
| Uniprot ID: |
R4RL1_HUMAN |
| Immunogen Region: |
220-420 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 220-420 of human RTN4RL1 (NP_848663.1). |
| Immunogen Sequence: |
LRRLTTLFLFNNSLSELQGE CLAPLGALEFLRLNGNPWDC GCRARSLWEWLQRFRGSSSA VPCVSPGLRHGQDLKLLRAE DFRNCTGPASPHQIKSHTLT TTDRAARKEHHSPHGPTRSK GHPHGPRPGHRKPGKNCTNP RNRNQISKAGAGKQAPELPD YAPDYQHKFSFDIMPTARPK RKGKCARRTPIRAPSGVQQA S |
| Tissue Specificity | Predominantly expressed in brain. Expressed at lower levels in kidney, lung, mammary gland, placenta, salivary gland, skeletal muscle and spleen. |
| Function | Cell surface receptor. Plays a functionally redundant role in postnatal brain development and in regulating axon regeneration in the adult central nervous system. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis.protection against apoptosis is probably mediated by MAG. Plays a role in inhibiting neurite outgrowth and axon regeneration via its binding to neuronal chondroitin sulfate proteoglycans. Binds heparin. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development. Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton. |
| Protein Name | Reticulon-4 Receptor-Like 1Nogo Receptor-Like 2Nogo-66 Receptor Homolog 2Nogo-66 Receptor-Related Protein 3Ngr3 |
| Database Links | Reactome: R-HSA-163125 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorMembrane RaftPerikaryonCell ProjectionLocalized To The Surface Of NeuronsIncluding Axons |
| Alternative Antibody Names | Anti-Reticulon-4 Receptor-Like 1 antibodyAnti-Nogo Receptor-Like 2 antibodyAnti-Nogo-66 Receptor Homolog 2 antibodyAnti-Nogo-66 Receptor-Related Protein 3 antibodyAnti-Ngr3 antibodyAnti-RTN4RL1 antibodyAnti-NGRH2 antibodyAnti-NGRL2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
