Anti-RTN4RL1 antibody (220-420) (STJ112061)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal RTN4RL1 (220-420) antibody for use in WB and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:4000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RTN4RL1 |
| Gene ID | 146760 |
| Uniprot ID | R4RL1_HUMAN |
| Immunogen Region | 220-420 |
| Immunogen Sequence | LRRLTTLFLFNNSLSELQGE CLAPLGALEFLRLNGNPWDC GCRARSLWEWLQRFRGSSSA VPCVSPGLRHGQDLKLLRAE DFRNCTGPASPHQIKSHTLT TTDRAARKEHHSPHGPTRSK GHPHGPRPGHRKPGKNCTNP RNRNQISKAGAGKQAPELPD YAPDYQHKFSFDIMPTARPK RKGKCARRTPIRAPSGVQQA S |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 220-420 of human RTN4RL1 (NP_848663.1). |
Additional Info
| Tissue Specificity | Predominantly expressed in brain. Expressed at lower levels in kidney, lung, mammary gland, placenta, salivary gland, skeletal muscle and spleen. |
| Function | Cell surface receptor. Plays a functionally redundant role in postnatal brain development and in regulating axon regeneration in the adult central nervous system. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis.protection against apoptosis is probably mediated by MAG. Plays a role in inhibiting neurite outgrowth and axon regeneration via its binding to neuronal chondroitin sulfate proteoglycans. Binds heparin. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development. Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton. |
| Protein Name | Reticulon-4 Receptor-Like 1Nogo Receptor-Like 2Nogo-66 Receptor Homolog 2Nogo-66 Receptor-Related Protein 3Ngr3 |
| Database Links | Reactome: R-HSA-163125 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorMembrane RaftPerikaryonCell ProjectionLocalized To The Surface Of NeuronsIncluding Axons |
| Alternative Antibody Names | Anti-Reticulon-4 Receptor-Like 1 antibodyAnti-Nogo Receptor-Like 2 antibodyAnti-Nogo-66 Receptor Homolog 2 antibodyAnti-Nogo-66 Receptor-Related Protein 3 antibodyAnti-Ngr3 antibodyAnti-RTN4RL1 antibodyAnti-NGRH2 antibodyAnti-NGRL2 antibody |
Information sourced from Uniprot.org