| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RTN3 (C-Term) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RTN3 |
| Gene ID: |
10313 |
| Uniprot ID: |
RTN3_HUMAN |
| Immunogen Region: |
C-Term |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human RTN3 (NP_006045.1). |
| Immunogen Sequence: |
YKSVIQAVQKSEEGHPFKAY LDVDITLSSEAFHNYMNAAM VHINRALKLIIRLFLVEDLV DSLKLAVFMWLMTYVGAVFN GITLLILAELLIFSVPIVYE KYKTQIDHYVGIARDQTKSI VEKIQAKLPGIAKKKAE |
| Tissue Specificity | Isoform 3 is widely expressed, with highest levels in brain, where it is enriched in neuronal cell bodies from gray matter (at protein level). Three times more abundant in macula than in peripheral retina. Isoform 1 is expressed at high levels in brain and at low levels in skeletal muscle. Isoform 2 is only found in melanoma. |
| Function | May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules. Also acts as an inflammation-resolving regulator by interacting with both TRIM25 and RIGI, subsequently impairing RIGI 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition. (Microbial infection) Plays a positive role in viral replication and pathogenesis of enteroviruses. |
| Protein Name | Reticulon-3Homolog Of Asy ProteinHapNeuroendocrine-Specific Protein-Like 2Nsp-Like Protein 2Neuroendocrine-Specific Protein-Like IiNsp-Like Protein IiNsplii |
| Database Links | Reactome: R-HSA-8849932 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinGolgi Apparatus Membrane |
| Alternative Antibody Names | Anti-Reticulon-3 antibodyAnti-Homolog Of Asy Protein antibodyAnti-Hap antibodyAnti-Neuroendocrine-Specific Protein-Like 2 antibodyAnti-Nsp-Like Protein 2 antibodyAnti-Neuroendocrine-Specific Protein-Like Ii antibodyAnti-Nsp-Like Protein Ii antibodyAnti-Nsplii antibodyAnti-RTN3 antibodyAnti-ASYIP antibodyAnti-NSPL2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
