• Confocal immunofluorescence analysis of Hela (A) , A431 (B) and THP-1 (C) cells using Rtn-3 monoclonal antibody (green). Blue: DRAQ5 fluorescent DNA dye.

Anti-RTN3 antibody [1E11] (STJ98370)

SKU:
STJ98370

Current Stock:
Host: Mouse
Applications: IF/ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Reticulon-3 is suitable for use in Immunofluorescence and ELISA research applications.
Clonality: Monoclonal
Clone ID: 1E11
Conjugation: Unconjugated
Isotype: IgG2a
Formulation: Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol.
Purification: Affinity purification
Dilution Range: IF 1:200-1:1000
ELISA 1:10000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: RTN3
Gene ID: 10313
Uniprot ID: RTN3_HUMAN
Specificity: Rtn-3 Monoclonal Antibody detects endogenous levels of Rtn-3 protein.
Immunogen: Purified recombinant fragment of Rtn-3 expressed in E. Coli.
Function May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules. Also acts as an inflammation-resolving regulator by interacting with both TRIM25 and RIGI, subsequently impairing RIGI 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition. (Microbial infection) Plays a positive role in viral replication and pathogenesis of enteroviruses.
Protein Name Reticulon-3
Homolog Of Asy Protein
Hap
Neuroendocrine-Specific Protein-Like 2
Nsp-Like Protein 2
Neuroendocrine-Specific Protein-Like Ii
Nsp-Like Protein Ii
Nsplii
Database Links Reactome: R-HSA-8849932
Cellular Localisation Endoplasmic Reticulum Membrane
Multi-Pass Membrane Protein
Golgi Apparatus Membrane
Alternative Antibody Names Anti-Reticulon-3 antibody
Anti-Homolog Of Asy Protein antibody
Anti-Hap antibody
Anti-Neuroendocrine-Specific Protein-Like 2 antibody
Anti-Nsp-Like Protein 2 antibody
Anti-Neuroendocrine-Specific Protein-Like Ii antibody
Anti-Nsp-Like Protein Ii antibody
Anti-Nsplii antibody
Anti-RTN3 antibody
Anti-ASYIP antibody
Anti-NSPL2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance