| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-R-spondin-4 (43-93 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RSPO4 |
| Gene ID: |
343637 |
| Uniprot ID: |
RSPO4_HUMAN |
| Immunogen Region: |
43-93 aa |
| Specificity: |
This antibody detects endogenous levels of RSPO4 at Human/Mouse |
| Immunogen: |
Synthesized peptide derived from the human RSPO4 at the amino acid range 43-93 |
| Function | Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. |
| Protein Name | R-Spondin-4Roof Plate-Specific Spondin-4Hrspo4 |
| Database Links | Reactome: R-HSA-4641263 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-R-Spondin-4 antibodyAnti-Roof Plate-Specific Spondin-4 antibodyAnti-Hrspo4 antibodyAnti-RSPO4 antibodyAnti-C20orf182 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
