| Short Description : | Rabbit polyclonal anti-R-spondin-4 (43-93 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-2000 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RSPO4 |
| Gene ID: | 343637 |
| Uniprot ID: | RSPO4_HUMAN |
| Immunogen: | Synthesized peptide derived from the human RSPO4 at the amino acid range 43-93 |
| Immunogen Region: | 43-93 aa |
| Specificity: | This antibody detects endogenous levels of RSPO4 at Human/Mouse |
| Function | Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. |
| Protein Name | R-Spondin-4Roof Plate-Specific Spondin-4Hrspo4 |
| Database Links | Reactome: R-HSA-4641263 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-R-Spondin-4 antibodyAnti-Roof Plate-Specific Spondin-4 antibodyAnti-Hrspo4 antibodyAnti-RSPO4 antibodyAnti-C20orf182 antibody |
Information sourced from Uniprot.org
