Anti-RRP1B antibody (STJA0009428)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human RRP1B
General Information
| Short Description | Rabbit polyclonal anti-Ribosomal RNA processing protein 1 homolog B for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RRP1B |
| Gene ID | 23076 |
| Uniprot ID | RRP1B_HUMAN |
| Immunogen | Synthesized peptide derived from human RRP1B |
| Specificity | This antibody detects endogenous levels of RRP1B at Human, Mouse |
Additional Info
| Function | Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1. Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus. Involved in regulation of mRNA splicing. Inhibits SIPA1 GTPase activity. Involved in regulating expression of extracellular matrix genes. Associates with chromatin and may play a role in modulating chromatin structure. (Microbial infection) Following influenza A virus (IAV) infection, promotes viral mRNA transcription by facilitating the binding of IAV RNA-directed RNA polymerase to capped mRNA. |
| Protein Name | Ribosomal Rna Processing Protein 1 Homolog BRrp1-Like Protein B |
| Database Links | |
| Cellular Localisation | NucleusNucleolusNucleoplasmChromosomePredominantly Located In The Nucleolus With A Small Amount Found In The NucleoplasmAssociates With The Perichromatin Region During Metaphase And With Cytoplasmic Foci During Telophase Before Reaccumulation In The Nucleolus During G2Associates With Heterochromatin And Euchromatin(Microbial Infection) Following Infection By Influenza A VirusPartially Translocates From The Nucleolus To The Nucleoplasm |
| Alternative Antibody Names | Anti-Ribosomal Rna Processing Protein 1 Homolog B antibodyAnti-Rrp1-Like Protein B antibodyAnti-RRP1B antibodyAnti-KIAA0179 antibody |
Information sourced from Uniprot.org