Anti-RRM2B antibody (Internal) (STJ94908)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the Internal region of human p53R2.
General Information
| Short Description | Rabbit polyclonal anti-Ribonucleoside-diphosphate reductase subunit M2 B (Internal) for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:40000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RRM2B |
| Gene ID | 50484 |
| Uniprot ID | RIR2B_HUMAN |
| Immunogen | Synthesized peptide derived from the Internal region of human p53R2. |
| Immunogen Region | Internal |
| Specificity | p53R2 Polyclonal Antibody detects endogenous levels of p53R2 protein. |
Additional Info
| Function | Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage. |
| Protein Name | Ribonucleoside-Diphosphate Reductase Subunit M2 BTp53-Inducible Ribonucleotide Reductase M2 BP53-Inducible Ribonucleotide Reductase Small Subunit 2-Like ProteinP53r2 |
| Database Links | Reactome: R-HSA-499943Reactome: R-HSA-5628897 |
| Cellular Localisation | CytoplasmNucleusTranslocates From Cytoplasm To Nucleus In Response To Dna Damage |
| Alternative Antibody Names | Anti-Ribonucleoside-Diphosphate Reductase Subunit M2 B antibodyAnti-Tp53-Inducible Ribonucleotide Reductase M2 B antibodyAnti-P53-Inducible Ribonucleotide Reductase Small Subunit 2-Like Protein antibodyAnti-P53r2 antibodyAnti-RRM2B antibodyAnti-P53R2 antibody |
Information sourced from Uniprot.org