| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RRM2B (1-351) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RRM2B |
| Gene ID: |
50484 |
| Uniprot ID: |
RIR2B_HUMAN |
| Immunogen Region: |
1-351 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-351 of human RRM2B (NP_056528.2). |
| Immunogen Sequence: |
MGDPERPEAAGLDQDERSSS DTNESEIKSNEEPLLRKSSR RFVIFPIQYPDIWKMYKQAQ ASFWTAEEVDLSKDLPHWNK LKADEKYFISHILAFFAASD GIVNENLVERFSQEVQVPEA RCFYGFQILIENVHSEMYSL LIDTYIRDPKKREFLFNAIE TMPYVKKKADWALRWIADRK STFGERVVAFAAVEGVFFSG SFAAIFWLKKRGLMPGLTFS NELISRDEGLHCDFACLMF |
| Tissue Specificity | Widely expressed at a high level in skeletal muscle and at a weak level in thymus. Expressed in epithelial dysplasias and squamous cell carcinoma. |
| Function | Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage. |
| Protein Name | Ribonucleoside-Diphosphate Reductase Subunit M2 BTp53-Inducible Ribonucleotide Reductase M2 BP53-Inducible Ribonucleotide Reductase Small Subunit 2-Like ProteinP53r2 |
| Database Links | Reactome: R-HSA-499943Reactome: R-HSA-5628897 |
| Cellular Localisation | CytoplasmNucleusTranslocates From Cytoplasm To Nucleus In Response To Dna Damage |
| Alternative Antibody Names | Anti-Ribonucleoside-Diphosphate Reductase Subunit M2 B antibodyAnti-Tp53-Inducible Ribonucleotide Reductase M2 B antibodyAnti-P53-Inducible Ribonucleotide Reductase Small Subunit 2-Like Protein antibodyAnti-P53r2 antibodyAnti-RRM2B antibodyAnti-P53R2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
