Anti-RRM2B antibody (1-351) (STJ110326)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal RRM2B (1-351) antibody for use in IF, ICC and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RRM2B |
| Gene ID | 50484 |
| Uniprot ID | RIR2B_HUMAN |
| Immunogen Region | 1-351 |
| Immunogen Sequence | MGDPERPEAAGLDQDERSSS DTNESEIKSNEEPLLRKSSR RFVIFPIQYPDIWKMYKQAQ ASFWTAEEVDLSKDLPHWNK LKADEKYFISHILAFFAASD |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human RRM2B (NP_056528.2). |
Additional Info
| Tissue Specificity | Widely expressed at a high level in skeletal muscle and at a weak level in thymus. Expressed in epithelial dysplasias and squamous cell carcinoma. |
| Function | Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage. |
| Protein Name | Ribonucleoside-Diphosphate Reductase Subunit M2 BTp53-Inducible Ribonucleotide Reductase M2 BP53-Inducible Ribonucleotide Reductase Small Subunit 2-Like ProteinP53r2 |
| Database Links | Reactome: R-HSA-499943Reactome: R-HSA-5628897 |
| Cellular Localisation | CytoplasmNucleusTranslocates From Cytoplasm To Nucleus In Response To Dna Damage |
| Alternative Antibody Names | Anti-Ribonucleoside-Diphosphate Reductase Subunit M2 B antibodyAnti-Tp53-Inducible Ribonucleotide Reductase M2 B antibodyAnti-P53-Inducible Ribonucleotide Reductase Small Subunit 2-Like Protein antibodyAnti-P53r2 antibodyAnti-RRM2B antibodyAnti-P53R2 antibody |
Information sourced from Uniprot.org