Anti-RPS6KA2 antibody (C-Term) (STJ71699)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-RPS6KA2 (C-Term) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Horse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:64000.WB: Approx 75kDa band observed in Rat Lung lysates (calculated MW of 83.2kDa according to Rat NP_476469.11). Recommended concentration: 0.01-0.03µg/ml. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | RPS6KA2 |
| Gene ID | 6196 |
| Uniprot ID | KS6A2_HUMAN |
| Accession Number | NP_066958.2; NP_001006933.1 |
| Immunogen Region | C-Term |
| Immunogen Sequence | EYLSPNQLSRQDVH |
| Specificity | This antibody is expected to recognize both reported isoforms (NP_066958.2; NP_001006933.1) |
Additional Info
| Post Translational Modifications | Activated by phosphorylation at Ser-218 by PDPK1. Autophosphorylated on Ser-377, as part of the activation process. May be phosphorylated at Thr-356 and Ser-360 by MAPK1/ERK2 and MAPK3/ERK1. N-terminal myristoylation results in an activated kinase in the absence of added growth factors. |
| Function | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells. |
| Protein Name | Ribosomal Protein S6 Kinase Alpha-2S6k-Alpha-290 Kda Ribosomal Protein S6 Kinase 2P90-Rsk 2P90rsk2Map Kinase-Activated Protein Kinase 1cMapk-Activated Protein Kinase 1cMapkap Kinase 1cMapkapk-1cRibosomal S6 Kinase 3Rsk-3Pp90rsk3 |
| Database Links | Reactome: R-HSA-198753Reactome: R-HSA-199920Reactome: R-HSA-2559582Reactome: R-HSA-437239Reactome: R-HSA-442742Reactome: R-HSA-444257Reactome: R-HSA-881907 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Ribosomal Protein S6 Kinase Alpha-2 antibodyAnti-S6k-Alpha-2 antibodyAnti-90 Kda Ribosomal Protein S6 Kinase 2 antibodyAnti-P90-Rsk 2 antibodyAnti-P90rsk2 antibodyAnti-Map Kinase-Activated Protein Kinase 1c antibodyAnti-Mapk-Activated Protein Kinase 1c antibodyAnti-Mapkap Kinase 1c antibodyAnti-Mapkapk-1c antibodyAnti-Ribosomal S6 Kinase 3 antibodyAnti-Rsk-3 antibodyAnti-Pp90rsk3 antibodyAnti-RPS6KA2 antibodyAnti-MAPKAPK1C antibodyAnti-RSK3 antibody |
Information sourced from Uniprot.org