| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RPRD1B (80-326) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:100-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RPRD1B |
| Gene ID: |
58490 |
| Uniprot ID: |
RPR1B_HUMAN |
| Immunogen Region: |
80-326 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 80-326 of human rprd1b (Q9NQG5). |
| Immunogen Sequence: |
EFESVLVDAFSHVAREADEG CKKPLERLLNIWQERSVYGG EFIQQLKLSMEDSKSPPPKA TEEKKSLKRTFQQIQEEEDD DYPGSYSPQDPSAGPLLTEE LIKALQDLENAASGDATVRQ KIASLPQEVQDVSLLEKITD KEAAERLSKTVDEACLLLAE YNGRLAAELEDRRQLARMLV EYTQNQKDVLSEKEKKLEEY KQKLARVTQVRKELKSHIQS LPDLSLLPNVTGGLAPLPS |
| Tissue Specificity | Preferentially expressed in a range of tumor tissues including colon, lung, liver, breast, prostate, stomach, uterine endometrium and cervical cancers with higher levels in tumors than in adjacent non-tumor tissue (at protein level). |
| Function | Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation. |
| Protein Name | Regulation Of Nuclear Pre-Mrna Domain-Containing Protein 1bCell Cycle-Related And Expression-Elevated Protein In Tumor |
| Database Links | Reactome: R-HSA-6807505 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Regulation Of Nuclear Pre-Mrna Domain-Containing Protein 1b antibodyAnti-Cell Cycle-Related And Expression-Elevated Protein In Tumor antibodyAnti-RPRD1B antibodyAnti-C20orf77 antibodyAnti-CREPT antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
