Anti-RPGRIP1L antibody (Internal) (STJ71282)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-RPGRIP1L (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human/Dog |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:64000.WB: Approx 150kDa band observed in Human Brain (Cerebellum) lysates (calculated MW of 151kDa according to NP_056087.2). Recommended concentration: 0.3-1µg/ml. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | RPGRIP1L |
| Gene ID | 23322 |
| Uniprot ID | FTM_HUMAN |
| Accession Number | NP_056087.2 |
| Immunogen Region | Internal |
| Immunogen Sequence | DKENNKAKRDILK |
Additional Info
| Function | Negatively regulates signaling through the G-protein coupled thromboxane A2 receptor (TBXA2R). May be involved in mechanisms like programmed cell death, craniofacial development, patterning of the limbs, and formation of the left-right axis. Involved in the organization of apical junctions.the function is proposed to implicate a NPHP1-4-8 module. Does not seem to be strictly required for ciliogenesis. Involved in establishment of planar cell polarity such as in cochlear sensory epithelium and is proposed to implicate stabilization of disheveled proteins. Involved in regulation of proteasomal activity at the primary cilium probably implicating association with PSDM2. |
| Protein Name | Protein FantomNephrocystin-8Rpgr-Interacting Protein 1-Like ProteinRpgrip1-Like Protein |
| Database Links | Reactome: R-HSA-5610787Reactome: R-HSA-5620912 |
| Cellular Localisation | CytoplasmCytoskeletonCilium Basal BodyCilium AxonemeMicrotubule Organizing CenterCentrosomeCell JunctionTight JunctionIn Cultured Renal CellsIt Localizes Diffusely In The Cytoplasm ButAs Cells Approach ConfluenceIt Accumulates To Basolateral Tight JunctionsLocalizes To The Ciliary Transition Zone |
| Alternative Antibody Names | Anti-Protein Fantom antibodyAnti-Nephrocystin-8 antibodyAnti-Rpgr-Interacting Protein 1-Like Protein antibodyAnti-Rpgrip1-Like Protein antibodyAnti-RPGRIP1L antibodyAnti-FTM antibodyAnti-KIAA1005 antibodyAnti-NPHP8 antibody |
Information sourced from Uniprot.org