Anti-RPE65 antibody (STJ502831)

SKU:
STJ502831-100

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Host: Rabbit
Applications: ELISA/IP/WB
Reactivity: Bovine/Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-RPE65 is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.51-0.63 µg/µl
Dilution Range: WB: 1:500
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Rpe65
Gene ID: 19892
Uniprot ID: RPE65_MOUSE
Immunogen: Synthetic peptide corresponding to unique amino acid sequence on mouse RPE65 protein.
Tissue Specificity Retinal pigment epithelium specific.
Post Translational Modifications Palmitoylation by LRAT regulates ligand binding specificity.the palmitoylated form (membrane form) specifically binds all-trans-retinyl-palmitate, while the soluble unpalmitoylated form binds all-trans-retinol (vitamin A).
Function Critical isomerohydrolase in the retinoid cycle involved in regeneration of 11-cis-retinal, the chromophore of rod and cone opsins. Catalyzes the cleavage and isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol which is further oxidized by 11-cis retinol dehydrogenase to 11-cis-retinal for use as visual chromophore. Essential for the production of 11-cis retinal for both rod and cone photoreceptors. Also capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carotenoid. The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT.
Protein Name Retinoid Isomerohydrolase
All-Trans-Retinyl-Palmitate Hydrolase
Lutein Isomerase
Meso-Zeaxanthin Isomerase
Retinal Pigment Epithelium-Specific 65 Kda Protein
Retinol Isomerase
Database Links Reactome: R-MMU-2453902
Cellular Localisation Cytoplasm
Cell Membrane
Lipid-Anchor
Microsome Membrane
Attached To The Membrane By A Lipid Anchor When Palmitoylated (Membrane Form)
Soluble When Unpalmitoylated
Undergoes Light-Dependent Intracellular Transport To Become More Concentrated In The Central Region Of The Retina Pigment Epithelium Cells
Alternative Antibody Names Anti-Retinoid Isomerohydrolase antibody
Anti-All-Trans-Retinyl-Palmitate Hydrolase antibody
Anti-Lutein Isomerase antibody
Anti-Meso-Zeaxanthin Isomerase antibody
Anti-Retinal Pigment Epithelium-Specific 65 Kda Protein antibody
Anti-Retinol Isomerase antibody
Anti-Rpe65 antibody

Information sourced from Uniprot.org

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