Anti-RP2 antibody (STJA0007803)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human RP2
General Information
| Short Description | Rabbit polyclonal anti-Protein XRP2 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RP2 |
| Gene ID | 6102 |
| Uniprot ID | XRP2_HUMAN |
| Immunogen | Synthesized peptide derived from human RP2 |
| Specificity | This antibody detects endogenous levels of RP2 at Human, Mouse |
Additional Info
| Post Translational Modifications | Myristoylated on Gly-2.which may be required for membrane targeting. Palmitoylated on Cys-3.which may be required for plasma membrane targeting (Probable). Mutation of Cys-3 targets the protein to internal membranes. |
| Function | Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane. Involved in localization of proteins, such as NPHP3, to the cilium membrane by inducing hydrolysis of GTP ARL3, leading to the release of UNC119 (or UNC119B). Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization. Acts as a guanine nucleotide dissociation inhibitor towards ADP-ribosylation factor-like proteins. |
| Protein Name | Protein Xrp2 |
| Database Links | Reactome: R-HSA-5624138 |
| Cellular Localisation | Cell MembraneLipid-AnchorCytoplasmic SideCell ProjectionCiliumDetected Predominantly At The Plasma Membrane Of Rod And Cone PhotoreceptorsNot Detected In The Nucleus |
| Alternative Antibody Names | Anti-Protein Xrp2 antibodyAnti-RP2 antibody |
Information sourced from Uniprot.org