Anti-ROR1 antibody [R11] (STJA0027504)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2ak
General Information
| Short Description | Mouse monoclonal Inactive Tyrosine-Protein Kinase Transmembrane Receptor Ror1 antibody for use in ELISA and FC in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/FC |
| Host | Mouse |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R11 |
| Isotype | IgG2ak |
| Conjugation | Unconjugated |
| Concentration | 1.37 mg/ml |
| Purification | Protein A/G purified from cell culture supernatant. |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | Ror1 |
| Gene ID | 26563 |
| Uniprot ID | ROR1_MOUSE |
Additional Info
| Function | Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling. In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells. Via IGFBP5 ligand, forms a complex with ERBB2 to enhance CREB oncogenic signaling. |
| Protein Name | Inactive Tyrosine-Protein Kinase Transmembrane Receptor Ror1Mror1Neurotrophic Tyrosine Kinase - Receptor-Related 1 |
| Database Links | Reactome: R-MMU-5140745 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinCell ProjectionAxon |
| Alternative Antibody Names | Anti-Inactive Tyrosine-Protein Kinase Transmembrane Receptor Ror1 antibodyAnti-Mror1 antibodyAnti-Neurotrophic Tyrosine Kinase - Receptor-Related 1 antibodyAnti-Ror1 antibodyAnti-Ntrkr1 antibody |
Information sourced from Uniprot.org