Anti-ROCK2 antibody (1300-1388) {Biotin} (STJ502823)

SKU:
STJ502823-100

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Host: Rabbit
Applications: ELISA/IHC/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ROCK2 (1300-1388) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Biotin
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.57 µg/µl
Dilution Range: WB: 1:500
DB: 1:10, 000
ELISA: 1:10, 000
IP: 1:200
IHC: 1:50-1:100
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: ROCK2
Gene ID: 9475
Uniprot ID: ROCK2_HUMAN
Immunogen Region: 1300-1388
Immunogen: Synthetic peptide taken within amino acid region 1300-1388 on human ROCK2 protein.
Tissue Specificity Expressed in the brain (at protein level).
Post Translational Modifications Phosphorylation at Tyr-722 reduces its binding to RHOA and is crucial for focal adhesion dynamics. Dephosphorylation by PTPN11 stimulates its RHOA binding activity. Cleaved by granzyme B during apoptosis. This leads to constitutive activation of the kinase and membrane blebbing.
Function Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation.
Protein Name Rho-Associated Protein Kinase 2
Rho Kinase 2
Rho-Associated - Coiled-Coil-Containing Protein Kinase 2
Rho-Associated - Coiled-Coil-Containing Protein Kinase Ii
Rock-Ii
P164 Rock-2
Database Links Reactome: R-HSA-3928662
Reactome: R-HSA-3928663
Reactome: R-HSA-416482
Reactome: R-HSA-416572
Reactome: R-HSA-4420097
Reactome: R-HSA-5627117
Reactome: R-HSA-8980692
Reactome: R-HSA-9013026
Reactome: R-HSA-9013106
Reactome: R-HSA-9013407
Reactome: R-HSA-9013422
Reactome: R-HSA-9679191
Cellular Localisation Cytoplasm
Cell Membrane
Peripheral Membrane Protein
Nucleus
Cytoskeleton
Microtubule Organizing Center
Centrosome
Cytoplasmic
And Associated With Actin Microfilaments And The Plasma Membrane
Alternative Antibody Names Anti-Rho-Associated Protein Kinase 2 antibody
Anti-Rho Kinase 2 antibody
Anti-Rho-Associated - Coiled-Coil-Containing Protein Kinase 2 antibody
Anti-Rho-Associated - Coiled-Coil-Containing Protein Kinase Ii antibody
Anti-Rock-Ii antibody
Anti-P164 Rock-2 antibody
Anti-ROCK2 antibody
Anti-KIAA0619 antibody

Information sourced from Uniprot.org

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