Anti-RNPS1 antibody (STJA0007795)

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	RNPS1
Gene ID:	10921
Uniprot ID:	RNPS1_HUMAN
Specificity:	This antibody detects endogenous levels of RNPS1 at Human, Mouse, Rat
Immunogen:	Synthesized peptide derived from human RNPS1

Post Translational Modifications	Phosphorylated on one or more of the four Ser/Thr residues (Ser-43, Thr-49, Ser-52 or Ser-53). Ser-53 phosphorylation site is important for splicing and translation stimulation activity in vitro.
Function	Part of pre- and post-splicing multiprotein mRNP complexes. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Enhances the formation of the ATP-dependent A complex of the spliceosome. Involved in both constitutive splicing and, in association with SRP54 and TRA2B/SFRS10, in distinctive modulation of alternative splicing in a substrate-dependent manner. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes).specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S).the activity is different from the established EJC assembly and function. Participates in mRNA 3'-end cleavage. Involved in UPF2-dependent nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Also mediates increase of mRNA abundance and translational efficiency. Binds spliced mRNA 20-25 nt upstream of exon-exon junctions.
Protein Name	Rna-Binding Protein With Serine-Rich Domain 1 Sr-Related Protein Ldc2
Database Links	Reactome: R-HSA-159236 Reactome: R-HSA-72163 Reactome: R-HSA-72187 Reactome: R-HSA-73856 Reactome: R-HSA-9010553 Reactome: R-HSA-975957
Cellular Localisation	Nucleus Nucleus Speckle Cytoplasm Nucleocytoplasmic Shuttling Protein Colocalizes With The Core Ejc Alyref/Thoc4 Nxf1 And Uap56 In The Nucleus And Nuclear Speckles
Alternative Antibody Names	Anti-Rna-Binding Protein With Serine-Rich Domain 1 antibody Anti-Sr-Related Protein Ldc2 antibody Anti-RNPS1 antibody Anti-LDC2 antibody

Information sourced from Uniprot.org

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