Anti-RNH1 antibody (7-461aa) [AT1H23] (STJA0041571)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2ak
ImmunogenRecombinant Ribonuclease inhibitor 1 (RNH1) (7-461aa) purified from E. coli
General Information
| Short Description | Mouse monoclonal anti-RNH1 (7-461aa) for use in ELISA, WB, ICC and IF in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/WB/ICC/IF |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | AT1H23 |
| Isotype | IgG2ak |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | By protein-G affinity chromatography |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RNH1 |
| Gene ID | 6050 |
| Uniprot ID | RINI_HUMAN |
| Accession Number | NP_002930 |
| Immunogen | Recombinant Ribonuclease inhibitor 1 (RNH1) (7-461aa) purified from E. coli |
| Immunogen Region | 7-461aa |
Additional Info
| Post Translational Modifications | The N-terminus is blocked. At least 30 of the 32 cysteine residues are in the reduced form. |
| Function | Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and angiogenin (ANG). May play a role in redox homeostasis. Required to inhibit the cytotoxic tRNA ribonuclease activity of ANG in the cytoplasm in absence of stress. Relocates to the nucleus in response to stress, relieving inhibition of ANG in the cytoplasm, and inhibiting the angiogenic activity of ANG in the nucleus. |
| Protein Name | Ribonuclease InhibitorPlacental Ribonuclease InhibitorPlacental Rnase InhibitorRibonuclease/Angiogenin Inhibitor 1Rai |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusLocalizes In The Cytoplasm In Absence Of StressTranslocates To The Nucleus In Response To Stress |
| Alternative Antibody Names | Anti-Ribonuclease Inhibitor antibodyAnti-Placental Ribonuclease Inhibitor antibodyAnti-Placental Rnase Inhibitor antibodyAnti-Ribonuclease/Angiogenin Inhibitor 1 antibodyAnti-Rai antibodyAnti-RNH1 antibodyAnti-PRI antibodyAnti-RNH antibody |
Information sourced from Uniprot.org