| Host: |
Goat |
| Applications: |
Pep-ELISA/WB/IHC |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-RNF7 (Internal) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
WB-1-3µg/mlIHC-5µg/mlELISA-antibody detection limit dilution 1:8000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
RNF7 |
| Gene ID: |
9616 |
| Uniprot ID: |
RBX2_HUMAN |
| Immunogen Region: |
Internal |
| Accession Number: |
NP_055060.1 |
| Specificity: |
This antibody is expected to recognize isoform 1 (NP_055060.1). |
| Immunogen Sequence: |
DACLRCQAENKQE |
| Post Translational Modifications | Phosphorylation by CK2 is required for efficient degradation of NFKBIA and CDKN1B. |
| Function | Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents. |
| Protein Name | Ring-Box Protein 2Rbx2Ckii Beta-Binding Protein 1Ckbbp1Ring Finger Protein 7Regulator Of Cullins 2Sensitive To Apoptosis Gene Protein |
| Database Links | Reactome: R-HSA-8951664Reactome: R-HSA-9705462Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Ring-Box Protein 2 antibodyAnti-Rbx2 antibodyAnti-Ckii Beta-Binding Protein 1 antibodyAnti-Ckbbp1 antibodyAnti-Ring Finger Protein 7 antibodyAnti-Regulator Of Cullins 2 antibodyAnti-Sensitive To Apoptosis Gene Protein antibodyAnti-RNF7 antibodyAnti-RBX2 antibodyAnti-ROC2 antibodyAnti-SAG antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
