Anti-RNF35/TRIM40 antibody (C-Term) (STJ70338)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-RNF35/TRIM40 (C-Term) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Approx 26kDa band observed in Human Placenta lysates (calculated MW of 26.1kDa according to NP_619645.1). Recommended concentration: 0.5-2µg/ml. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | TRIM40 |
| Gene ID | 135644 |
| Uniprot ID | TRI40_HUMAN |
| Accession Number | NP_619645.1 |
| Immunogen Region | C-Term |
| Immunogen Sequence | GVSELLLQPPQKL |
Additional Info
| Function | E3 ubiquitin-protein ligase that plays a role in the limitation of the innate immune response. Mediates inhibition of the RLR signaling pathway by ubiquitinating RIGI and IFIH1 receptors, leading to their proteasomal degradation. Promotes also the neddylation of IKBKG/NEMO, stabilizing NFKBIA, and thereby inhibiting of NF-kappa-B nuclear translocation and activation. |
| Protein Name | E3 Ubiquitin Ligase Trim40Probable E3 Nedd8-Protein LigaseRing Finger Protein 35 |
| Alternative Antibody Names | Anti-E3 Ubiquitin Ligase Trim40 antibodyAnti-Probable E3 Nedd8-Protein Ligase antibodyAnti-Ring Finger Protein 35 antibodyAnti-TRIM40 antibodyAnti-RNF35 antibody |
Information sourced from Uniprot.org