| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | OBI1 |
| Gene ID: | 79596 |
| Uniprot ID: | OBI1_HUMAN |
| Immunogen Region: | 600 aa |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 600 to the C-terminus of human RNF219 (NP_078822.3). |
| Immunogen Sequence: | QLENGSEWKPTSFFLLSPSD QEMNEDFSLHSSSCPVTNEI KPPSCLFQTEFSQGILLSSS HRLFEDQRFGSSLFKMSSEM HSLHNHLQSPWSTSFVPEKR NKNVNQSTKRKIQSSLSSAS PSKATKS |
| Post Translational Modifications | Auto-ubiquitinated. |
| Function | E3 ubiquitin ligase essential for DNA replication origin activation during S phase. Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase. |
| Protein Name | Orc Ubiquitin Ligase 1Obi1Ring Finger Protein 219 |
| Cellular Localisation | ChromosomeAssociation To Chromatin Is Cell Cycle-RegulatedAbsent From Mitotic ChromosomesIs Associated With Chromatin From G1 And Partially Released From Chromatin From Mid S-Phase |
| Alternative Antibody Names | Anti-Orc Ubiquitin Ligase 1 antibodyAnti-Obi1 antibodyAnti-Ring Finger Protein 219 antibodyAnti-OBI1 antibodyAnti-C13orf7 antibodyAnti-RNF219 antibody |
Information sourced from Uniprot.org