Anti-ADGRL2 antibody (551-600 aa) (STJ93907)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human LPHN2 at the amino acid range 551-600
General Information
| Short Description | Rabbit polyclonal anti-Adhesion G protein-coupled receptor L2 (551-600 aa) for use in IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:5000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ADGRL2 |
| Gene ID | 23266 |
| Uniprot ID | AGRL2_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human LPHN2 at the amino acid range 551-600 |
| Immunogen Region | 551-600 aa |
| Specificity | Latrophilin-2 Polyclonal Antibody detects endogenous levels of Latrophilin-2 protein. |
Additional Info
| Post Translational Modifications | Autoproteolytically processed at the GPS region of the GAIN-B domain.this cleavage modulates receptor activity. |
| Function | Orphan adhesion G-protein coupled receptor (aGPCR), which mediates synapse specificity. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Following G-protein coupled receptor activation, associates with cell adhesion molecules that are expressed at the surface of adjacent cells to direct synapse specificity. Specifically mediates the establishment of perforant-path synapses on CA1-region pyramidal neurons in the hippocampus. Localizes to postsynaptic spines in excitatory synapses in the S.lacunosum-moleculare and interacts with presynaptic cell adhesion molecules, such as teneurins, promoting synapse formation. |
| Protein Name | Adhesion G Protein-Coupled Receptor L2Calcium-Independent Alpha-Latrotoxin Receptor 2Cirl-2Latrophilin Homolog 1Latrophilin-2Lectomedin-1 |
| Database Links | |
| Cellular Localisation | Postsynaptic Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Adhesion G Protein-Coupled Receptor L2 antibodyAnti-Calcium-Independent Alpha-Latrotoxin Receptor 2 antibodyAnti-Cirl-2 antibodyAnti-Latrophilin Homolog 1 antibodyAnti-Latrophilin-2 antibodyAnti-Lectomedin-1 antibodyAnti-ADGRL2 antibodyAnti-KIAA0786 antibodyAnti-LEC1 antibodyAnti-LPHH1 antibodyAnti-LPHN2 antibody |
Information sourced from Uniprot.org