Anti-RNF19B antibody (272-322 aa) (STJ197996)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human RN19B at the amino acid range 272-322
General Information
| Short Description | Rabbit polyclonal anti-E3 ubiquitin-protein ligase RNF19B (272-322 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:1000-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RNF19B |
| Gene ID | 127544 |
| Uniprot ID | RN19B_HUMAN |
| Immunogen | Synthesized peptide derived from the human RN19B at the amino acid range 272-322 |
| Immunogen Region | 272-322 aa |
| Specificity | This antibody detects endogenous levels of human RN19B |
Additional Info
| Function | E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1. Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells. Protects against staurosporin-induced cell death. |
| Protein Name | E3 Ubiquitin-Protein Ligase Rnf19bIbr Domain-Containing Protein 3Natural Killer Lytic-Associated MoleculeRing Finger Protein 19b |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | Cytoplasmic Granule MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Rnf19b antibodyAnti-Ibr Domain-Containing Protein 3 antibodyAnti-Natural Killer Lytic-Associated Molecule antibodyAnti-Ring Finger Protein 19b antibodyAnti-RNF19B antibodyAnti-IBRDC3 antibodyAnti-NKLAM antibody |
Information sourced from Uniprot.org