| Function | E3 ubiquitin-protein ligase that catalyzes 'Lys-27', 'Lys-48'- or 'Lys-63'-linked polyubiquitin chains formation and plays a role in different biological processes such as modulation of immune response, cytoskeletal dynamics or protein homeostasis. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with 'Lys-48' linkages and COR1A with 'Lys-63' linkages leading to their degradation, down-regulation of these cytoskeletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse. Functions in the patterning of the dorsal ectoderm.sensitizes ectoderm to respond to neural-inducing signals. Plays a positive role in innate immune response by promoting 'Lys-63'-linked ubiquitination of TBK1 after RNA- or DNA-virus infection. Regulates alveolar macrophage activation and neutrophil infiltration by interacting with TLR4, targeting it for degradation, and inhibiting NF-kappa-B activation, hence decreasing pro-inflammatory cytokines. Negatively regulates the IL-3/STAT5 signaling pathway by facilitating 'Lys-27'-linked polyubiquitination of IL3RA leading to its degradation via lysosomal pathway. Directly regulates the N-glycosylation process in the endoplasmic reticulum by targeting the glycosyl-transferase RPN1 for ubiquitination and degradation. Other substrates targeted for degradation by RNF128 include transmembrane proteins CD40L, CD83 or the tetraspanin CD151. |
| Protein Name | E3 Ubiquitin-Protein Ligase Rnf128Gene Related To Anergy In Lymphocytes ProteinGrailRing Finger Protein 128Ring-Type E3 Ubiquitin Transferase Rnf128 |
| Database Links | Reactome: R-HSA-5689880Reactome: R-HSA-5689896 |
| Cellular Localisation | CytoplasmEndomembrane SystemSingle-Pass Membrane ProteinCytoskeletonPerinuclear RegionLocalized In An Asymmetric Perinuclear Punctate MannerLocalizes To The Internal Pool Of The Transferrin Recycling Endosomal PathwayPartially Colocalized With The Endoplasmic Reticulum Resident Hspa5With Golgi Resident Stx5And With The Late Endosomal Gtpase Rab7a |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Rnf128 antibodyAnti-Gene Related To Anergy In Lymphocytes Protein antibodyAnti-Grail antibodyAnti-Ring Finger Protein 128 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Rnf128 antibodyAnti-RNF128 antibody |
Information sourced from Uniprot.org
