| Host: | Rabbit |
| Applications: | WB/IHC |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-RING finger protein 112 (377-427 aa) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 IHC-P 1:50-300 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RNF112 |
| Gene ID: | 7732 |
| Uniprot ID: | RN112_HUMAN |
| Immunogen Region: | 377-427 aa |
| Specificity: | This antibody detects endogenous levels of RN112 at Human/Mouse/Rat |
| Immunogen: | Synthesized peptide derived from the human RN112 at the amino acid range 377-427 |
| Post Translational Modifications | Auto-ubiquitinated. |
| Function | E3 ubiquitin-protein ligase that plays an important role in neuronal differentiation, including neurogenesis and gliogenesis, during brain development. During embryonic development initiates neuronal differentiation by inducing cell cycle arrest at the G0/G1 phase through up-regulation of cell-cycle regulatory proteins. Plays a role not only in the fetal period during the development of the nervous system, but also in the adult brain, where it is involved in the maintenance of neural functions and protection of the nervous tissue cells from oxidative stress-induced damage. Exhibits GTPase and E3 ubiquitin-protein ligase activities. Regulates dendritic spine density and synaptic neurotransmission.its ability to hydrolyze GTP is involved in the maintenance of dendritic spine density. |
| Protein Name | Ring Finger Protein 112 Brain Finger Protein Zinc Finger Protein 179 |
| Cellular Localisation | Membrane Multi-Pass Membrane Protein Peripheral Membrane Protein Cytoplasm Nucleus Nuclear Body Nucleoplasm Endosome Cytoplasmic Vesicle Secretory Vesicle Synaptic Vesicle Postsynaptic Density Perikaryon Cell Projection Neuron Projection Predominantly In The Nucleus But Some Amounts Were Also Found In The Cytoplasm Oxidative Stress Stimulates Its Shuttling From The Cytoplasm Into The Nucleus Recruited To Nuclear Bodies Via Its Interaction With Zbtb16 Localizes To The Cell Soma And Neuritis And Only Slightly To The Nucleus In The Neurons Of Most Brain Areas |
| Alternative Antibody Names | Anti-Ring Finger Protein 112 antibody Anti-Brain Finger Protein antibody Anti-Zinc Finger Protein 179 antibody Anti-RNF112 antibody Anti-BFP antibody Anti-ZNF179 antibody |
Information sourced from Uniprot.org