| Short Description : | Rabbit monoclonal anti-RNA Polymerases I/II/III Subunit ABC1 for use in WB and IHC-P in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC-P |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | R05-8J5 |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 0.3 mg/mL |
| Purification: | Affinity Purified |
| Dilution Range: | WB 1:500-1:1000IHC 1:50-1:100 |
| Formulation: | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction: | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
| Gene Symbol: | POLR2E |
| Gene ID: | 5434 |
| Uniprot ID: | RPAB1_HUMAN |
| Immunogen: | A synthetic peptide of human POLR2E |
| Function | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPABC1 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. |
| Protein Name | Dna-Directed Rna Polymerases I - Ii - And Iii Subunit Rpabc1Rna Polymerases I - Ii - And Iii Subunit Abc1Dna-Directed Rna Polymerase Ii 23 Kda PolypeptideDna-Directed Rna Polymerase Ii Subunit ERpb5 HomologXap4 |
| Database Links | Reactome: R-HSA-112382Reactome: R-HSA-113418Reactome: R-HSA-167152Reactome: R-HSA-167158Reactome: R-HSA-167160Reactome: R-HSA-167161Reactome: R-HSA-167162Reactome: R-HSA-167172Reactome: R-HSA-167200Reactome: R-HSA-167238Reactome: R-HSA-167242Reactome: R-HSA-167243Reactome: R-HSA-167246Reactome: R-HSA-167287Reactome: R-HSA-167290Reactome: R-HSA-168325Reactome: R-HSA-1834949Reactome: R-HSA-203927Reactome: R-HSA-427413Reactome: R-HSA-5250924Reactome: R-HSA-5578749Reactome: R-HSA-5601884Reactome: R-HSA-5617472Reactome: R-HSA-674695Reactome: R-HSA-6781823Reactome: R-HSA-6781827Reactome: R-HSA-6782135Reactome: R-HSA-6782210Reactome: R-HSA-6796648Reactome: R-HSA-6803529Reactome: R-HSA-6807505Reactome: R-HSA-72086Reactome: R-HSA-72163Reactome: R-HSA-72165Reactome: R-HSA-72203Reactome: R-HSA-73762Reactome: R-HSA-73772Reactome: R-HSA-73776Reactome: R-HSA-73779Reactome: R-HSA-73780Reactome: R-HSA-73863Reactome: R-HSA-73980Reactome: R-HSA-749476Reactome: R-HSA-75953Reactome: R-HSA-75955Reactome: R-HSA-76042Reactome: R-HSA-76061Reactome: R-HSA-76066Reactome: R-HSA-76071Reactome: R-HSA-77075Reactome: R-HSA-8851708Reactome: R-HSA-9018519Reactome: R-HSA-9670095 |
| Cellular Localisation | NucleusNucleolus |
| Alternative Antibody Names | Anti-Dna-Directed Rna Polymerases I - Ii - And Iii Subunit Rpabc1 antibodyAnti-Rna Polymerases I - Ii - And Iii Subunit Abc1 antibodyAnti-Dna-Directed Rna Polymerase Ii 23 Kda Polypeptide antibodyAnti-Dna-Directed Rna Polymerase Ii Subunit E antibodyAnti-Rpb5 Homolog antibodyAnti-Xap4 antibodyAnti-POLR2E antibody |
Information sourced from Uniprot.org
