Anti-RMND5A antibody (200-270) (STJ117123)

Name: Anti-RMND5A antibody (200-270) (STJ117123)
SKU: STJ117123
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ117123

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Short Description	Rabbit polyclonal RMND5A (200-270) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	RMND5A
Gene ID	64795
Uniprot ID	RMD5A_HUMAN
Immunogen Region	200-270
Immunogen Sequence	ISLLMGGTTNQREALQYAKN FQPFALNHQKDIQVLMGSLV YLRQGIENSPYVHLLDANQW ADICDIFTRDA
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 200-270 of human RMND5A (NP_073617.1).

Function	Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. Catalytic activity of the complex is required for normal cell proliferation. The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1.
Protein Name	E3 Ubiquitin-Protein Transferase Rmnd5a P44ctlh Protein Rmd5 Homolog A
Database Links	Reactome: R-HSA-9861718
Cellular Localisation	Nucleus Nucleoplasm Cytoplasm
Alternative Antibody Names	Anti-E3 Ubiquitin-Protein Transferase Rmnd5a antibody Anti-P44ctlh antibody Anti-Protein Rmd5 Homolog A antibody Anti-RMND5A antibody

Information sourced from Uniprot.org