Anti-RMI2 antibody (1-147) (STJ110821)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal RMI2 (1-147) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RMI2 |
| Gene ID | 116028 |
| Uniprot ID | RMI2_HUMAN |
| Immunogen Region | 1-147 |
| Immunogen Sequence | MAAAADSFSGGPAGVRLPRS PPLKVLAEQLRRDAEGGPGA WRLSRAAAGRGPLDLAAVWM QGRVVMADRGEARLRDPSGD FSVRGLERVPRGRPCLVPGK YVMVMGVVQACSPEPCLQAV KMTDLSDNPIHESMWELEVE DLHRNIP |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-147 of human RMI2 (NP_689521.1). |
Additional Info
| Post Translational Modifications | Phosphorylated during mitosis. |
| Function | Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is required to regulate sister chromatid segregation and to limit DNA crossover. Essential for the stability, localization, and function of BLM, TOP3A, and complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM. |
| Protein Name | Recq-Mediated Genome Instability Protein 2Hrmi2Blm-Associated Protein Of 18 KdaBlap18 |
| Database Links | Reactome: R-HSA-5685938Reactome: R-HSA-5685942Reactome: R-HSA-5693554Reactome: R-HSA-5693568Reactome: R-HSA-5693579Reactome: R-HSA-5693607Reactome: R-HSA-5693616Reactome: R-HSA-6804756Reactome: R-HSA-69473Reactome: R-HSA-9701192Reactome: R-HSA-9704331Reactome: R-HSA-9704646Reactome: R-HSA-9709570Reactome: R-HSA-9709603 |
| Cellular Localisation | NucleusColocalizes With Blm At Nuclear Dna Repair Foci |
| Alternative Antibody Names | Anti-Recq-Mediated Genome Instability Protein 2 antibodyAnti-Hrmi2 antibodyAnti-Blm-Associated Protein Of 18 Kda antibodyAnti-Blap18 antibodyAnti-RMI2 antibodyAnti-C16orf75 antibody |
Information sourced from Uniprot.org