| Tissue Specificity | Expressed in hair follicles and skin. |
| Post Translational Modifications | May be phosphorylated by MAP3K2 and MAP3K3. Proteolytically cleaved by during Fas-induced apoptosis. Cleavage at Asp-388 and Asp-426. Polyubiquitinated with 'Lys-48' and 'Lys-63'-linked chains by BIRC2/c-IAP1 and BIRC3/c-IAP2, leading to activation of NF-kappa-B. |
| Function | Serine/threonine protein kinase. Required for embryonic skin development and correct skin homeostasis in adults, via phosphorylation of PKP1 and subsequent promotion of keratinocyte differentiation and cell adhesion. It is a direct transcriptional target of TP63. Plays a role in NF-kappa-B activation. |
| Protein Name | Receptor-Interacting Serine/Threonine-Protein Kinase 4Ankyrin Repeat Domain-Containing Protein 3Pkc-Delta-Interacting Protein Kinase |
| Cellular Localisation | CytoplasmMembranePeripheral Membrane Protein |
| Alternative Antibody Names | Anti-Receptor-Interacting Serine/Threonine-Protein Kinase 4 antibodyAnti-Ankyrin Repeat Domain-Containing Protein 3 antibodyAnti-Pkc-Delta-Interacting Protein Kinase antibodyAnti-RIPK4 antibodyAnti-ANKRD3 antibodyAnti-DIK antibody |
Information sourced from Uniprot.org
