Anti-RIOK3 antibody (271-320 aa) (STJ95831)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human RIOK3 at the amino acid range 271-320
General Information
| Short Description | Rabbit polyclonal anti-Serine/threonine-protein kinase RIO3 (271-320 aa) for use in WB, ELISA and IHC in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA/IHC |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-P 1:50-300ELISA 2000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RIOK3 |
| Gene ID | 8780 |
| Uniprot ID | RIOK3_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human RIOK3 at the amino acid range 271-320 |
| Immunogen Region | 271-320 aa |
| Specificity | SUDD Polyclonal Antibody detects endogenous levels of SUDD protein. |
Additional Info
| Post Translational Modifications | Autophosphorylated (in vitro). |
| Function | Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitment of TBK1 to IRF3. Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling. Can inhibit CASP10 isoform 7-mediated activation of the NF-kappaB signaling pathway. May play a role in the biogenesis of the 40S ribosomal subunit. Involved in the processing of 21S pre-rRNA to the mature 18S rRNA. |
| Protein Name | Serine/Threonine-Protein Kinase Rio3Rio Kinase 3Sudd Homolog |
| Database Links | Reactome: R-HSA-6791226 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase Rio3 antibodyAnti-Rio Kinase 3 antibodyAnti-Sudd Homolog antibodyAnti-RIOK3 antibodyAnti-SUDD antibody |
Information sourced from Uniprot.org