Anti-RIOK2 antibody (253-552) (STJ114016)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal RIOK2 (253-552) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RIOK2 |
| Gene ID | 55781 |
| Uniprot ID | RIOK2_HUMAN |
| Immunogen Region | 253-552 |
| Immunogen Sequence | TSHPNAEWYFDRDVKCIKDF FMKRFSYESELFPTFKDIRR EDTLDVEVSASGYTKEMQAD DELLHPLGPDDKNIETKEGS EFSFSDGEVAEKAEVYGSEN ESERNCLEESEGCYCRSSGD PEQIKEDSLSEESADARSFE MTEFNQALEEIKGQVVENNS VTEFSEEKNRTENYNRQDGQ RVQGGVPAGSDEYEDECPHL IALSSLNREFRPFRDEENVG AMNQYRTRTLSITSSGSAV |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 253-552 of human RIOK2 (NP_060813.2). |
Additional Info
| Post Translational Modifications | Autophosphorylated (in vitro). Phosphorylation at Ser-335, Ser-380, Ser-548 by PLK1 affects the timing of the metaphase-anaphase transition. |
| Function | Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA. Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function. |
| Protein Name | Serine/Threonine-Protein Kinase Rio2Rio Kinase 2 |
| Database Links | Reactome: R-HSA-6791226 |
| Cellular Localisation | CytoplasmExported Out Of The Nucleus Via Its Nes In A Xpo1-Dependent Manner |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase Rio2 antibodyAnti-Rio Kinase 2 antibodyAnti-RIOK2 antibodyAnti-RIO2 antibody |
Information sourced from Uniprot.org